Two birds with one stone: a novel motif for ACh receptor assembly quality control

被引：10

作者：

Mei, L ^{[1
]}

Xiong, WC

机构：

[1] Univ Alabama, Dept Neurobiol, Birmingham, AL 35294 USA

[2] Univ Alabama, Dept Phys Med & Rehabil, Birmingham, AL 35294 USA

[3] Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA

来源：

TRENDS IN NEUROSCIENCES | 2003年 / 26卷 / 04期

关键词：

D O I：

10.1016/S0166-2236(03)00036-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Assembly of ACh receptors is under tight quality control. Only functional ACh receptors are expressed on the cell surface; unassembled subunits are retained in the endoplasmic reticulum (ER). In a recent elegant study, Wang and colleagues have identified a novel motif in the M1 domain of the ACh-receptor subunit that is responsible for ER retention and degradation of unassembled subunits. This signal appears to play an important role in regulating surface trafficking of functional ACh receptors.

引用

收藏

页码：178 / 181

页数：4

相关论文

共 23 条

[1]

BONIFACINO J S, 1991, Current Opinion in Cell Biology, V3, P592, DOI 10.1016/0955-0674(91)90028-W

[2] Removal of multiple arginine-framed trafficking signals overcomes misprocessing of ΔF508 CFTR present in most patients with cystic fibrosis [J].

Chang, XB ;

Cui, LY ;

Hou, YX ;

Jensen, TJ ;

Aleksandrov, AA ;

Mengos, A ;

Riordan, JR .

MOLECULAR CELL, 1999, 4 (01) :137-142

[3] Setting the standards: Quality control in the secretory pathway [J].

Ellgaard, L ;

Molinari, M ;

Helenius, A .

SCIENCE, 1999, 286 (5446) :1882-1888

[4] The action of molecular chaperones in the early secretory pathway [J].

Fewell, SW ;

Travers, KJ ;

Weissman, JS ;

Brodsky, JL .

ANNUAL REVIEW OF GENETICS, 2001, 35 :149-191

[5] Perspective - Ion channel assembly: Creating structures that function [J].

Green, WN .

JOURNAL OF GENERAL PHYSIOLOGY, 1999, 113 (02) :163-169

[6] The chaperone protein 14-3-3η interacts with the nicotinic acetylcholine receptor α4 subunit -: Evidence for a dynamic role in subunit stabilization [J].

Jeanclos, EM ;

Lin, L ;

Treuil, MW ;

Rao, J ;

DeCoster, MA ;

Anand, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (30) :28281-28290

[7] Emerging structure of the nicotinic acetylcholine receptors [J].

Karlin, A .

NATURE REVIEWS NEUROSCIENCE, 2002, 3 (02) :102-114

[8] Perspective - Determinants responsible for assembly of the nicotinic acetylcholine receptor [J].

Keller, SH ;

Taylor, P .

JOURNAL OF GENERAL PHYSIOLOGY, 1999, 113 (02) :171-176

[9] Adjacent basic amino acid residues recognized by the COPI complex and ubiquitination govern endoplasmic reticulum to cell surface trafficking of the nicotinic acetylcholine receptor α-subunit [J].

Keller, SH ;

Lindstrom, J ;

Ellisman, M ;

Taylor, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (21) :18384-18391

[10] COATOMER IS ESSENTIAL FOR RETRIEVAL OF DILYSINE-TAGGED PROTEINS TO THE ENDOPLASMIC-RETICULUM [J].

LETOURNEUR, F ;

GAYNOR, EC ;

HENNECKE, S ;

DEMOLLIERE, C ;

DUDEN, R ;

EMR, SD ;

RIEZMAN, H ;

COSSON, P .

CELL, 1994, 79 (07) :1199-1207