Melatonin receptors in the eye: Location, second messengers and role in ocular physiology

被引：100

作者：

Alarma-Estrany, Pilar ^{[1
]}

Pintor, Jesus ^{[1
]}

机构：

[1] Univ Complutense Madrid, EU Opt, Dept Bioquim, Madrid 28037, Spain

来源：

PHARMACOLOGY & THERAPEUTICS | 2007年 / 113卷 / 03期

关键词：

melatonin; melatonin receptors; eye;

D O I：

10.1016/j.pharmthera.2006.11.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The pineal hormone melatonin, an important regulator of circadian and seasonal rhythms, has a role in ocular pathophysiology. In addition to the pineal gland, melatonin synthesis is carried out in several ocular structures. Moreover, specific melatonin receptors have been located in the retina, comea, ciliary body, lens, choroid and sclera, which suggests that cells in these tissues may be targets for melatonin action. This review summarizes the current knowledge about melatonin receptor subtypes with the emphasis on those melatonin receptors, which have been identified in ocular tissues and their possible roles in biochemical and physiological processes in the eye. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：507 / 522

页数：16

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