Genomic imprinting - insights from studies in mice

被引：17

作者：

Ferguson-Smith, A ^{[1
]}

Lin, SP ^{[1
]}

Tsai, CE ^{[1
]}

Youngson, N ^{[1
]}

Tevendale, M ^{[1
]}

机构：

[1] Univ Cambridge, Dept Anat, Cambridge CB2 3DY, England

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2003年 / 14卷 / 01期

关键词：

DNA methylation; epigenetic control; genomic imprinting; targeted mutagenesis; uniparental disomy;

D O I：

10.1016/S1084-9521(02)00171-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A subset of mammalian genes is controlled by genomic imprinting. This process causes a gene to be expressed from only one chromosome homologue depending on whether it originally came from the egg or the sperm. Parental origin-specific gene regulation is controlled by epigenetic modifications to DNA and chromatin. Genomic imprinting is therefore a useful model system to study the epigenetic control of genome function. Here we consider the value of the mouse as an experimental organism to address questions about the role of imprinted genes, about the regulation of mono-allelic gene expression and about the evolution of the imprinting function and mechanism. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：43 / 49

页数：7

共 28 条

[1] Appropriate expression of the mouse H19 gene utilises three or more distinct enhancer regions spread over more than 130 kb [J].