Birth defects in infants conceived by intracytoplasmic sperm injection: an alternative interpretation

Objective: To test the hypothesis that liveborn infants conceived by intracytoplasmic sperm injection are at an increased risk of having a major birth defect. Design: Reclassification of the birth defects reported in infants born after intracytoplasmic sperm injection in Belgium and comparison with prevalence estimated in Western Australian population by means of same classification system. Setting and subjects: 420 liveborn infants who were conceived after intracytoplasmic sperm injection in Belgium and 100 454 liveborn infants in Western Australia delivered during die same period, Main outcome measures: Estimates of birth prevalence of birth defects and comparisons of odds ratios between cohort conceived after intracytoplasmic sperm injection and Western Australian infants, Results: Infants horn after intracytoplasmic sperm injection were twice as likely as Western Australian infants to hare a major birth defect (odds ratio 2.03 (95% confidence interval 1.40 to 2.93); P = 0.0002) and nearly 50% more likely to hale a minor defect (1.49 (0.48 to 4.66): P = 0.49). Secondary data-led analyses, to he interpreted with caution, found an excess of major cardiovascular defects (odds ratio 3.99), genitourinary defects (1.33), and gastrointestinal defects (1.84), in particular cleft palate (5.11) and diaphragmatic hernia (7.73). Conclusions: These results do not confirm the apparently reassuring results published by the Belgian researchers of intracytoplasmic sperm injection, Further research is clearly required. Meanwhile, doctors practising intracytoplasmic sperm injection should bear this alternative interpretation in mind when they counsel couples and obtain informed consent for the procedure.