Loss of nicotinic acetylcholine receptor subunits α4 and α7 in the cerebral cortex of Parkinson patients

被引:50
作者
Burghaus, L
Schütz, U
Krempel, U
Lindstrom, J
Schröder, H
机构
[1] Univ Cologne, Dept Anat Neuroanat 2, D-50931 Cologne, Germany
[2] Univ Penn, Sch Med, Dept Neurosci, Philadelphia, PA 19104 USA
关键词
Parkinson's disease; Alzheimer's disease; nicotinic acetylcholine receptor; human cerebral cortex; western blot;
D O I
10.1016/S1353-8020(03)00028-2
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Cerebral cortical cholinergic deficits, represented by a decrease in choline acetyltransferase activity, severe losses of nicotinic binding sites as well as cell degeneration in the basal forebrain can be observed in neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. The potential role of nicotinic acetylcholine receptor subunits as pharmacological targets for the treatment of cognitive deficits raises the question as to what extent these subunits are affected in neurodegenerative diseases. We here report on a significant decrease of the alpha(4) and the alpha(7) nicotinic acetylcholine receptor subunit in cortices of Parkinson patients which turns out to be similar to recent findings in Alzheimer patients. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:243 / 246
页数:4
相关论文
共 25 条
[1]   COMPARATIVE ALTERATIONS OF NICOTINIC AND MUSCARINIC BINDING-SITES IN ALZHEIMERS AND PARKINSONS DISEASES [J].
AUBERT, I ;
ARAUJO, DM ;
CECYRE, D ;
ROBITAILLE, Y ;
GAUTHIER, S ;
QUIRION, R .
JOURNAL OF NEUROCHEMISTRY, 1992, 58 (02) :529-541
[2]   Cellular expression of α7 nicotinic acetylcholine receptor protein in the temporal cortex in Alzheimer's and Parkinson's disease -: A stereological approach [J].
Banerjee, C ;
Nyengaard, JR ;
Wevers, A ;
de Vos, RAI ;
Steur, ENHJ ;
Lindstrom, J ;
Pilz, K ;
Nowacki, S ;
Bloch, W ;
Schröder, H .
NEUROBIOLOGY OF DISEASE, 2000, 7 (06) :666-672
[3]  
BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[4]  
Burghaus L, 2000, MOL BRAIN RES, V76, P385
[5]   IMMUNOCYTOCHEMICAL LOCALIZATION OF THE ALPHA-7 SUBUNIT OF THE NICOTINIC ACETYLCHOLINE-RECEPTOR IN THE RAT CENTRAL-NERVOUS-SYSTEM [J].
DELTORO, ED ;
JUIZ, JM ;
PENG, X ;
LINDSTROM, J ;
CRIADO, M .
JOURNAL OF COMPARATIVE NEUROLOGY, 1994, 349 (03) :325-342
[6]   CHOLINERGIC-DEPENDENT COGNITIVE DEFICITS IN PARKINSONS-DISEASE [J].
DUBOIS, B ;
DANZE, F ;
PILLON, B ;
CUSIMANO, G ;
LHERMITTE, F ;
AGID, Y .
ANNALS OF NEUROLOGY, 1987, 22 (01) :26-30
[7]   Human post-mortem striatal α4β2 nicotinic acetylcholine receptor density in schizophrenia and Parkinson's syndrome [J].
Durany, N ;
Zöchling, R ;
Boissl, KW ;
Paulus, W ;
Ransmayr, G ;
Tatschner, T ;
Danielczyk, W ;
Jellinger, K ;
Deckert, J ;
Riederer, P .
NEUROSCIENCE LETTERS, 2000, 287 (02) :109-112
[8]   EVIDENCE IN POSTMORTEM BRAIN-TISSUE FOR DECREASED NUMBERS OF HIPPOCAMPAL NICOTINIC RECEPTORS IN SCHIZOPHRENIA [J].
FREEDMAN, R ;
HALL, M ;
ADLER, LE ;
LEONARD, S .
BIOLOGICAL PSYCHIATRY, 1995, 38 (01) :22-33
[9]   Decreased protein levels of nicotinic receptor subunits in the hippocampus and temporal cortex of patients with Alzheimer's disease [J].
Guan, ZZ ;
Zhang, X ;
Ravid, R ;
Nordberg, A .
JOURNAL OF NEUROCHEMISTRY, 2000, 74 (01) :237-243
[10]   ALTERED MUSCARINIC AND NICOTINIC RECEPTOR DENSITIES IN CORTICAL AND SUBCORTICAL BRAIN-REGIONS IN PARKINSONS-DISEASE [J].
LANGE, KW ;
WELLS, FR ;
JENNER, P ;
MARSDEN, CD .
JOURNAL OF NEUROCHEMISTRY, 1993, 60 (01) :197-203