Effects of slime produced by clinical isolates of coagulase-negative staphylococci on activities of various antimicrobial agents

被引：68

作者：

Souli, M ^{[1
]}

Giamarellou, H ^{[1
]}

机构：

[1] Univ Athens, Laiko Gen Hosp, Dept Propedeut Med 1, Sch Med, Athens 11527, Greece

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 04期

关键词：

D O I：

10.1128/AAC.42.4.939

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A novel in vitro semiquantitative method was developed to investigate the influence of staphylococcal slime on the activities of 22 antimicrobial agents. Pefloxacin, teicoplanin, and vancomycin demonstrated remarkable decreases in efficacy: 30, 52, and 63%, respectively. The activity of rifampin was not significantly reduced (0.99%), whereas all other agents tested were modestly affected (<15% decrease). These data could be influential in the treatment of implant-associated infections caused by slime-producing staphylococci.

引用

页码：939 / 941

页数：3

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