Tumor-released microvesicles as vehicles of immunosuppression

被引：317

作者：

Valenti, Roberta ^{[1
]}

Huber, Veronica ^{[1
]}

Iero, Manuela ^{[1
]}

Filipazzi, Paola ^{[1
]}

Parmiani, Giorgio ^{[1
]}

Rivoltini, Licia ^{[1
]}

机构：

[1] Univ Milan, Unit Immunotherapy Human Tumors, Fdn IRCCS, Ist Nazl Tumori, I-20133 Milan, Italy

来源：

CANCER RESEARCH | 2007年 / 67卷 / 07期

关键词：

D O I：

10.1158/0008-5472.CAN-07-0520

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor-released microvesicles, or exosomes, which are abundant in the body fluids of patients with cancer, are likely to be involved in tumor progression. We recently showed that microvesicles released by human melanoma and colorectal carcinoma cells can promote the differentiation of monocytes to myeloid-derived suppressor cells which support tumoral growth and immune escape. These findings underscore an important role for these extracellular organelles in remodeling tumor-stromal interactions to promote malignancy.

引用

页码：2912 / 2915

页数：4

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