Genetic aberrations in oral or head and neck squamous cell carcinoma 2: chromosomal aberrations

被引:127
作者
Scully, C
Field, JK
Tanzawa, H
机构
[1] Univ London, Univ Coll London, Eastman Dent Inst Oral Hlth Care Sci, London WC1X 8LD, England
[2] Univ Liverpool, Mol Genet & Oncol Grp, Liverpool L69 3BX, Merseyside, England
[3] Roy Castle Int Ctr Lung Canc Res, Liverpool, Merseyside, England
[4] Chiba Univ, Dept Oral Surg, Chuo Ku, Chiba 2608670, Japan
关键词
cancer; oral; genetics; chromosomes;
D O I
10.1016/S1368-8375(00)00021-X
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Carcinogenesis is the result of a series of genetic mutations resulting in unregulated growth of a clone of cells and the development of malignant lesion that is largely monoclonal though, with the evolution of further genetic changes, there develops a degree of heterogeneity in the tumour. DNA technology, especially allelic imbalance (loss of heterozygosity) studies have identified chromosomal changes in oral carcinoma and head and neck squamous cell carcinoma (SCCHN), suggestive of the involvement of tumour suppressor genes (TSGs), particularly in chromosomes 3, 9, 11 and 17. The regions most commonly identified have included 3p, especially 3p14.2 (FHIT); 3p24, and 3p21.3. where the TSGs involved are as yet unidentified; 9p21 where p16(INK4A/MTS-1] is the main target TSG; and 17p13 where p53 is the major target TSC. Over-expression of oncogenes, genes mainly involved in cell signalling, especially those on chromosome 11 (PRAD-1 in particular) and 17 (H-ras) and mutations in DNA repair genes, have also been implicated in the carcinogenesis of SCCHN. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:311 / 327
页数:17
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