CC-CHEMOKINE LIGAND 18/PULMONARY ACTIVATION-REGULATED CHEMOKINE EXPRESSION IN THE CNS WITH SPECIAL REFERENCE TO TRAUMATIC BRAIN INJURIES AND NEOPLASTIC DISORDERS

被引：25

作者：

Chang, C. -Y. ^{[2
,3
]}

Lee, Y. -H. ^{[2
,4
]}

Leu, S. -J. ^{[5
]}

Wang, C. -Y. ^{[4
]}

Wei, C. -P. ^{[1
]}

Hung, K. -S. ^{[6
]}

pai, M. -H ^{[3
]}

Tsai, M. -D. ^{[1
,7
]}

Wu, C. -H. ^{[2
,8
,9
]}

机构：

[1] Shin Kong Wu Ho Su Mem Hosp, Dept Neurosurg, Taipei 111, Taiwan

[2] Taipei Med Univ, Grad Inst Med Sci, Taipei, Taiwan

[3] Taipei Med Univ, Coll Med, Dept Anat, Taipei, Taiwan

[4] Taipei Med Univ, Coll Med, Dept Physiol, Taipei, Taiwan

[5] Taipei Med Univ, Dept Microbiol & Immunol, Taipei, Taiwan

[6] Taipei Med Univ, Wan Fang Hosp, Dept Neurosurg, Taipei, Taiwan

[7] Fu Jen Catholic Univ, Sch Med, Taipei, Taiwan

[8] Natl Def Med Ctr, Dept Biol & Anat, Taipei 114, Taiwan

[9] Natl Def Med Ctr, Inst Biol & Anat, Taipei 114, Taiwan

来源：

NEUROSCIENCE | 2010年 / 165卷 / 04期

关键词：

CC-chemokine; glia; microglia; macrophages; glioma; source; lesion; CENTRAL-NERVOUS-SYSTEM; MONOCYTE CHEMOATTRACTANT PROTEIN-1; MESSENGER-RNA EXPRESSION; HUMAN-MALIGNANT GLIOMA; RECEPTOR EXPRESSION; CEREBROSPINAL-FLUID; HUMAN ASTROCYTOMAS; CELL INFILTRATION; DENDRITIC CELLS; MACROPHAGES;

D O I：

10.1016/j.neuroscience.2009.11.050

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pulmonary activation-regulated chemokine (PARC) now designated CC-chemokine ligand 18 (CCL18) has been shown to play a significant role in the pathogenesis of various tissue injuries and diseases in a proinflammatory or immune suppressive way to limit or support the inflammation or disease. While much is known about the roles of CCL18/PARC in non-neural tissues, its expression in the CNS has remained largely unexplored and controversial. Using reverse transcription polymerase chain reaction (RT-PCR) and double immunohistochemical staining, we analyzed the expression of CCL18/PARC in the human brain with special reference to traumatic brain injuries and tumors. The RT-PCR analysis revealed the expression of CCL18/PARC mRNA both in the traumatic brain and glioma tissues examined. Immunoexpression of CCL18/PARC protein was consistently detected in all cases of traumatic brain injuries examined by immunohistochemical staining. Double immunofluorescence labeling has extended the study that CCL18/PARC positive cells were macrophages/microglia, astrocytes or neurons. The CCL18/PARC expression was localized in macrophage-like cells in two of eight glioblastoma tissues whose cancer cells were CCL18/PARC negative. Unexpectedly, CCL18/PARC mRNA weakly and constitutively expressed by glioblastoma cell line was upregulated after endotoxin stimulation. The present results indicated a significant production of CCL18/PARC in different CNS traumatic and neoplasm tissues by specific cellular elements expressing the chemokine. An anti-inflammatory mechanism jointly exerted by these cells via CCL18/PARC may be involved in the CNS immunity after traumatic injury and tumorigenesis. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：1233 / 1243

页数：11

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