Single-nucleotide evolutionary constraint scores highlight disease-causing mutations

被引:135
作者
Cooper, Gregory M. [1 ]
Goode, David L. [2 ]
Ng, Sarah B. [1 ]
Sidow, Arend [2 ,3 ]
Bamshad, Michael J. [1 ,4 ]
Shendure, Jay [1 ]
Nickerson, Deborah A. [1 ]
机构
[1] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA
[2] Stanford Univ, Dept Genet, Stanford, CA 94305 USA
[3] Stanford Univ, Dept Genet, Stanford, CA 94305 USA
[4] Univ Washington, Dept Pediat, Seattle, WA 98195 USA
关键词
D O I
10.1038/nmeth0410-250
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:250 / 251
页数:2
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