A new approach to (-)-anisomycin

被引：19

作者：

Huang, PQ ^{[1
]}

Wang, SL ^{[1
]}

Ruan, YP ^{[1
]}

Gao, JX ^{[1
]}

机构：

[1] Xiamen Univ, Dept Chem, Fujian 361005, Peoples R China

来源：

NATURAL PRODUCT LETTERS | 1998年 / 11卷 / 02期

基金：

中国国家自然科学基金;

关键词：

anisomycin; malic acid; reductive alkylation; asymmetric synthesis;

D O I：

10.1080/10575639808041204

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

(R)-(-)-1-Benzyloxycarbonyl-2-(4-methoxyphenyl)methyl-3-pyrroline (16) was prepared from (S)-malic acid. The key steps involved a highly regio and trans stereoselective reductive alkylation of N-benzylmalimide (4). This constitutes a formal asymmetric synthesis of natural (-)-anisomycin (2).

引用

页码：101 / 106

页数：6

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