Molecular Pathways Underlying Cholesterol Homeostasis

被引：133

作者：

Afonso, Milessa Silva ^{[1
]}

Machado, Roberta Marcondes ^{[2
]}

Lavrador, Maria Silvia ^{[2
]}

Rocha Quintao, Eder Carlos ^{[2
]}

Moore, Kathryn J. ^{[1
,3
]}

Lottenberg, Ana Maria ^{[2
,4
]}

机构：

[1] NYU, Sch Med, Dept Med, Marc & Ruti Bell Vasc Biol & Dis Program,Leon H C, New York, NY 10016 USA

[2] Univ Sao Paulo, Lab Lipides LIM 10, Hosp Clin HCFMUSP, Fac Med, BR-05403000 Sao Paulo, SP, Brazil

[3] NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USA

[4] Fac Israelita Ciencias Saude, BR-05403000 Sao Paulo, SP, Brazil

来源：

NUTRIENTS | 2018年 / 10卷 / 06期

基金：

巴西圣保罗研究基金会; 美国国家卫生研究院;

关键词：

cholesterol; molecular pathways; cardiovascular disease; cholesterol homeostasis; dietary cholesterol; LOW-DENSITY-LIPOPROTEIN; ESTER TRANSFER PROTEIN; CASSETTE TRANSPORTER A1; E3 UBIQUITIN LIGASE; STEROL-REGULATED UBIQUITINATION; X RECEPTOR AGONIST; DIETARY-CHOLESTEROL; EGG CONSUMPTION; ENDOPLASMIC-RETICULUM; SQUALENE MONOOXYGENASE;

D O I：

10.3390/nu10060760

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Cholesterol is an essential molecule that exerts pleiotropic actions. Although its presence is vital to the cell, its excess can be harmful and, therefore, sustaining cholesterol homeostasis is crucial to maintaining proper cellular functioning. It is well documented that high plasma cholesterol concentration increases the risk of atherosclerotic heart disease. In the last decades, several studies have investigated the association of plasma cholesterol concentrations and the risk of cardiovascular diseases as well as the signaling pathways involved in cholesterol homeostasis. Here, we present an overview of several mechanisms involved in intestinal cholesterol absorption, the regulation of cholesterol synthesis and uptake. We also discuss the importance of reverse cholesterol transport and transintestinal cholesterol transport to maintain cholesterol homeostasis and prevent atherosclerosis development. Additionally, we discuss the influence of dietary cholesterol on plasma cholesterol concentration and the new recommendations for cholesterol intake in a context of a healthy dietary pattern.

引用

页数：18

共 134 条

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