Positive and negative regulation of cellular sensitivity to anti-cancer drugs by FGF-2

被引：15

作者：

Coleman, AB ^{[1
]}

机构：

[1] Beckman Res Inst City Hope, Div Mol Med, Duarte, CA 91010 USA

来源：

DRUG RESISTANCE UPDATES | 2003年 / 6卷 / 02期

关键词：

FGF-2; FGFR; chemotherapy; drug resistance;

D O I：

10.1016/S1368-7646(03)00023-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The development of resistance to chemotherapy by tumor cells remains a constant limitation to the treatment of cancer. Over the last several years, fibroblast growth factor-2 (FGF-2) has emerged as a growth factor that is capable of modifying the sensitivity of normal and tumor cells to anti-cancer drugs. FGF-2 can produce both drug resistance and drug sensitization in different cell types treated with a variety of cytotoxic agents. An understanding of the differential cellular trafficking and biological activities of the multiple FGF-2 isoforms will help in determining the circumstances tinder which FGF-2 acts to inhibit versus potentiate drug action. Recent advances suggest that expression of FGF-2 in tumor cells is involved with loss of response to chemotherapy in vivo. Thus, the manipulation of FGF-2 activities to increase the effectiveness of chemotherapeutic agents may have important clinical implications. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：85 / 94

页数：10

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