Invasive aspergillosis in solid-organ transplantation: report of eight cases and review of the literature

被引:24
作者
Ergin, F
Arslan, H
Azap, A
Demirhan, B
Karakayali, H
Haberal, M
机构
[1] Baskent Univ, Dept Clin Mocrobiol & Infect Dis, Fac Med, TR-06490 Ankara, Turkey
[2] Baskent Univ, Fac Med, Dept Pathol, TR-06490 Ankara, Turkey
[3] Baskent Univ, Fac Med, Dept Surg, TR-06490 Ankara, Turkey
关键词
invasive aspergillosis; solid-organ transplantation; fungal infection;
D O I
10.1111/j.1432-2277.2003.tb00300.x
中图分类号
R61 [外科手术学];
学科分类号
摘要
Invasive fungal infections are life-threatening complications in solid-organ transplantation. Although the rate of fungal infections in transplant recipients is lower than that of other infections, the mortality rate is higher. The most frequent fungi isolated from these kinds of infections are Candida spp. and Aspergillus spp. We retrospectively evaluated the clinical and laboratory findings in eight patients who were treated for invasive aspergillosis (IA) at our center. This report describes these cases and discusses the relevant literature.
引用
收藏
页码:280 / 286
页数:7
相关论文
共 38 条
[1]   Incidence and significance of Aspergillus cultures following liver and kidney transplantation [J].
Brown, RS ;
Lake, JR ;
Katzman, BA ;
Ascher, NL ;
Somberg, KA ;
Emond, JC ;
Roberts, JP .
TRANSPLANTATION, 1996, 61 (04) :666-669
[2]   Improved management of invasive pulmonary aspergillosis in neutropenic patients using early thoracic computed tomographic scan and surgery [J].
Caillot, D ;
Casasnovas, O ;
Bernard, A ;
Couaillier, JF ;
Durand, C ;
Cuisenier, B ;
Solary, E ;
Piard, F ;
Petrella, T ;
Bonnin, A ;
Couillault, G ;
Dumas, M ;
Guy, H .
JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (01) :139-147
[3]   Human platelets damage Aspergillus fumigatus hyphae and may supplement killing by neutrophils [J].
Christin, L ;
Wysong, DR ;
Meshulam, T ;
Hastey, R ;
Simons, ER ;
Diamond, RD .
INFECTION AND IMMUNITY, 1998, 66 (03) :1181-1189
[4]   RISK-FACTORS FOR INVASIVE FUNGAL-INFECTIONS COMPLICATING ORTHOTOPIC LIVER-TRANSPLANTATION [J].
COLLINS, LA ;
SAMORE, MH ;
ROBERTS, MS ;
LUZZATI, R ;
JENKINS, RL ;
LEWIS, WD ;
KARCHMER, AW .
JOURNAL OF INFECTIOUS DISEASES, 1994, 170 (03) :644-652
[5]   Guidelines for the investigation of invasive fungal infections in haematological malignancy and solid organ transplantation [J].
Denning, DW ;
Evans, EGV ;
Kibbler, CC ;
Richardson, MD ;
Roberts, MM ;
Rogers, TR ;
Warnock, DW ;
Warren, RE .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1997, 16 (06) :424-436
[6]   NIAID MYCOSES STUDY-GROUP MULTICENTER TRIAL OF ORAL ITRACONAZOLE THERAPY FOR INVASIVE ASPERGILLOSIS [J].
DENNING, DW ;
LEE, JY ;
HOSTETLER, JS ;
PAPPAS, P ;
KAUFFMAN, CA ;
DEWSNUP, DH ;
GALGIANI, JN ;
GRAYBILL, JR ;
SUGAR, AM ;
CATANZARO, A ;
GALLIS, H ;
PERFECT, JR ;
DOCKERY, B ;
DISMUKES, WE ;
STEVENS, DA .
AMERICAN JOURNAL OF MEDICINE, 1994, 97 (02) :135-144
[7]   Therapeutic outcome in invasive aspergillosis [J].
Denning, DW .
CLINICAL INFECTIOUS DISEASES, 1996, 23 (03) :608-615
[8]  
DENNING DW, 1990, REV INFECT DIS, V12, P1147
[9]   Echinocandins and pneumocandins - a new antifungal class with a novel mode of action [J].
Denning, DW .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1997, 40 (05) :611-614
[10]   An EORTC international multicenter randomized trial (EORTC number 19923) comparing two dosages of liposomal amphotericin B for treatment of invasive aspergillosis [J].
Ellis, M ;
Spence, D ;
de Pauw, B ;
Meunier, F ;
Marinus, A ;
Collette, L ;
Sylvester, R ;
Meis, J ;
Boogaerts, M ;
Selleslag, D ;
Kremery, V ;
von Sinner, W ;
MacDonald, P ;
Doyen, C ;
Vandercam, B .
CLINICAL INFECTIOUS DISEASES, 1998, 27 (06) :1406-1412