Assisted reproductive technologies and the risk of birth defects - a systematic review

被引:449
作者
Hansen, M
Bower, C
Milne, E
de Klerk, N
Kurinczuk, JJ
机构
[1] Univ Western Australia, Telethon Inst Child Hlth Res, Ctr Child Hlth Res, Perth, WA 6872, Australia
[2] Univ Oxford, Natl Perinatal Epidemiol Unit, Oxford OX3 7LF, England
基金
英国医学研究理事会;
关键词
assisted reproductive technology; congenital malformations; IVF; meta-analysis; systematic review;
D O I
10.1093/humrep/deh593
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Background: The risk of birth defects in infants born following assisted reproductive technology (ART) treatment is a controversial question. Most publications examining the prevalence of birth defects in ICSI and IVF infants compared to spontaneously conceived infants have serious methodological limitations; despite this, most researchers have concluded that there is no increased risk. Methods: We carried out a systematic review to identify all papers published by March 2003 with data relating to the prevalence of birth defects in infants conceived following IVF and/or ICSI compared with spontaneously conceived infants. Independent expert reviewers used criteria defined a priori to determine whether studies were suitable for inclusion in a meta-analysis. Fixed effects meta-analysis was performed for all studies and reviewer-selected studies. Results: Twenty-five studies were identified for review. Two-thirds of these showed a 25% or greater increased risk of birth defects in ART infants. The results of meta-analyses of the seven reviewer-selected studies and of all 25 studies suggest a statistically significant 30-40% increased risk of birth defects associated with ART. Conclusions: Pooled results from all suitable published studies suggest that children born following ART are at increased risk of birth defects compared with spontaneous conceptions. This information should be made available to couples seeking ART treatment.
引用
收藏
页码:328 / 338
页数:11
相关论文
共 81 条
  • [1] Impact of infertility treatments on the health of newborns
    Addor, V
    Santos-Eggimann, B
    Fawer, CL
    Paccaud, F
    Calame, A
    [J]. FERTILITY AND STERILITY, 1998, 69 (02) : 210 - 215
  • [2] [Anonymous], MIDDLE E FERTIL SOC
  • [3] Congenital malformations in 4224 children conceived after IVF
    Anthony, S
    Buitendijk, SE
    Dorrepaal, CA
    Lindner, K
    Braat, DDM
    den Ouden, AL
    [J]. HUMAN REPRODUCTION, 2002, 17 (08) : 2089 - 2095
  • [4] The children of assisted reproduction - the need for an ongoing debate
    Barlow, DH
    [J]. HUMAN REPRODUCTION, 2002, 17 (05) : 1133 - 1134
  • [5] BERAL V, 1990, BMJ-BRIT MED J, V300, P1229
  • [6] Berg I, 2001, Lakartidningen, V98, P4020
  • [7] Berg I, 2001, LAKARTIDNINGEN, V98, P4024
  • [8] Deliveries and children born after in-vitro fertilisation in Sweden 1982-95:: a retrospective cohort study
    Bergh, T
    Ericson, A
    Hillensjö, T
    Nygren, KG
    Wennerholm, UB
    [J]. LANCET, 1999, 354 (9190) : 1579 - 1585
  • [9] Expressing the magnitude of adverse effects in case-control studies: "the number of patients needed to be treated for one additional patient to be harmed"
    Bjerre, LM
    LeLorier, J
    [J]. BRITISH MEDICAL JOURNAL, 2000, 320 (7233) : 503 - 506
  • [10] Neonatal data on a cohort of 2889 infants born after ICSI (1991-1999) and of 2995 infants born after IVF (1983-1999)
    Bonduelle, M
    Liebaers, I
    Deketelaere, V
    Derde, MP
    Camus, M
    Devroey, P
    Van Steirteghem, A
    [J]. HUMAN REPRODUCTION, 2002, 17 (03) : 671 - 694