The distribution of amyloid beta protein deposition in the corpus striatum of patients with Alzheimer's disease

被引：25

作者：

Brilliant, MJ

Elble, RJ

Ghobrial, M

Struble, RG

机构：

[1] SO ILLINOIS UNIV, SCH MED, CTR ALZHEIMER DIS & RELATED DISORDERS, SPRINGFIELD, IL 62794 USA

[2] SO ILLINOIS UNIV, SCH MED, DEPT NEUROL, SPRINGFIELD, IL 62794 USA

[3] SO ILLINOIS UNIV, SCH MED, DEPT PATHOL, SPRINGFIELD, IL 62794 USA

[4] SO ILLINOIS UNIV, SCH MED, DEPT PSYCHIAT, SPRINGFIELD, IL 62794 USA

来源：

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY | 1997年 / 23卷 / 04期

关键词：

Alzheimer's disease; basal ganglia; amyloid;

D O I：

10.1111/j.1365-2990.1997.tb01302.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The distribution of amyloid beta peptide (A beta) was quantified in the corpus striatum and pallidum of 10 patients with Alzheimer's disease (AD) and three patients with both Alzheimer's disease and Parkinson's disease (AD-PD), A beta occurred almost exclusively in plaques that did not have neurites or amyloid cores, Caudate, accumbens nuclei and rostral putamen contained more of the diffuse plaques than did caudal putamen, No diffuse plaques were found in the neighbouring globus pallidus, This distribution of A beta deposition may reflect the distribution of diseased synaptic cortical afferents rather than a putative vascular source of A beta.

引用

页码：322 / 325

页数：4

共 20 条

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