Ulcerative colitis

被引：2938

作者：

Ungaro, Ryan ^{[1
]}

Mehandru, Saurabh ^{[1
,2
]}

Allen, Patrick B. ^{[3
]}

Peyrin-Biroulet, Laurent ^{[4
]}

Colombel, Jean-Frederic ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Div Gastroenterol, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Inst Immunol, New York, NY 10029 USA

[3] Ulster Hosp, Div Gastroenterol, Belfast, Antrim, North Ireland

[4] Univ Hosp Nancy Brabois, Dept Gastroenterol, Vandoeuvre Les Nancy, France

来源：

LANCET | 2017年 / 389卷 / 10080期

关键词：

INFLAMMATORY-BOWEL-DISEASE; EVIDENCE-BASED CONSENSUS; POUCH-ANAL ANASTOMOSIS; C-REACTIVE PROTEIN; CLOSTRIDIUM-DIFFICILE INFECTION; VENOUS THROMBOEMBOLIC EVENTS; ENVIRONMENTAL RISK-FACTORS; INNATE LYMPHOID-CELLS; CROHNS-DISEASE; FECAL CALPROTECTIN;

D O I：

10.1016/S0140-6736(16)32126-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ulcerative colitis is a chronic inflammatory disease affecting the colon, and its incidence is rising worldwide. The pathogenesis is multifactorial, involving genetic predisposition, epithelial barrier defects, dysregulated immune responses, and environmental factors. Patients with ulcerative colitis have mucosal inflammation starting in the rectum that can extend continuously to proximal segments of the colon. Ulcerative colitis usually presents with bloody diarrhoea and is diagnosed by colonoscopy and histological findings. The aim of management is to induce and then maintain remission, defined as resolution of symptoms and endoscopic healing. Treatments for ulcerative colitis include 5-aminosalicylic acid drugs, steroids, and immunosuppressants. Some patients can require colectomy for medically refractory disease or to treat colonic neoplasia. The therapeutic armamentarium for ulcerative colitis is expanding, and the number of drugs with new targets will rapidly increase in coming years.

引用

页码：1756 / 1770

页数：15

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