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Building a pharmacological lexicon: Small molecule discovery in academia
被引:41
作者:

Lazo, John S.
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机构: Univ Pittsburgh, Dept Pharmacol, Pittsburgh Mol Lib Screening Ctr, Drug Discovery Inst, Pittsburgh, PA 15261 USA

Brady, Linda S.
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机构: Univ Pittsburgh, Dept Pharmacol, Pittsburgh Mol Lib Screening Ctr, Drug Discovery Inst, Pittsburgh, PA 15261 USA

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机构:
[1] Univ Pittsburgh, Dept Pharmacol, Pittsburgh Mol Lib Screening Ctr, Drug Discovery Inst, Pittsburgh, PA 15261 USA
[2] NIMH, Mol Screening Ctr Network, Div Neurosci & Basic Behav Sci, Bethesda, MD 20892 USA
[3] Emory Univ, Dept Pharmacol, Emory Chem Biol Discovery Ctr, Atlanta, GA 30322 USA
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D O I:
10.1124/mol.107.035113
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
Small molecules are powerful pharmacological tools to dissect biological events. There is now considerable interest in expanding efforts to identify and use small molecules targeting proteins encoded in the genomes of humans and pathogenic organisms. Integration of the principles of molecular pharmacology with contemporary high-throughput and high-content screening technologies is essential for the success of these discovery activities. We present some of the challenges and opportunities provided by the Molecular Library Screening Centers Network (MLSCN), which is a National Institutes of Health Roadmap Initiative.
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