Regulation of G1 cyclin dependent kinases in the mammalian cell cycle

被引：570

作者：

Ekholm, SV ^{[1
]}

Reed, SI

机构：

[1] Karolinska Inst, Canc Ctr Karolinska, Dept Oncol Pathol, S-17176 Stockholm, Sweden

[2] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2000年 / 12卷 / 06期

关键词：

D O I：

10.1016/S0955-0674(00)00151-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Cyclin-dependent kinases are the key regulators of cell-cycle transitions. In mammalian cells, Cdk2, Cdk4, Cdk6 and associated cyclins control the G(1) to S phase transition. Because proper regulation of this transition is critical for an organism's survival, these protein kinases are exquisitely regulated at different mechanistic levels and in response to a large variety of intrinsic and extrinsic signals.

引用

页码：676 / 684

页数：9

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