Protective effect of rutin on LPS-induced acute lung injury via down-regulation of MIP-2 expression and MMP-9 activation through inhibition of Akt phosphorylation

被引：70

作者：

Chen, Wen-Ying ^{[1
]}

Huang, Yi-Chun ^{[2
]}

Yang, Ming-Ling ^{[3
]}

Lee, Chien-Ying ^{[4
,5
]}

Chen, Chun-Jung ^{[6
]}

Yeh, Chung-Hsin ^{[7
,8
]}

Pan, Pin-Ho ^{[9
]}

Horng, Chi-Ting ^{[10
,11
]}

Kuo, Wu-Hsien ^{[12
,13
]}

Kuan, Yu-Hsiang ^{[4
,5
]}

机构：

[1] Natl Chung Hsing Univ, Dept Vet Med, Taichung 40227, Taiwan

[2] Natl Chung Hsing Univ, Sch Hlth, Taichung 40227, Taiwan

[3] Chung Shan Med Univ, Sch Med, Dept Anat, Taichung 402, Taiwan

[4] Chung Shan Med Univ, Sch Med, Dept Pharmacol, 110 Sec 1,Jianguo N Rd, Taichung 402, Taiwan

[5] Chung Shan Med Univ, Sch Med, Dept Pharm, Taichung 402, Taiwan

[6] Taichung Vet Gen Hosp, Dept Educ & Res, Taichung, Taiwan

[7] Show Chwan Mem Hosp, Dept Neurol, Changhua, Taiwan

[8] Hung Kuang Univ, Dept Nursing, Coll Med & Nursing, Taichung, Taiwan

[9] Tungs Taichung MetroHarbor Hosp, Dept Pediat, Taichung, Taiwan

[10] Kaohsiung Armed Forced Gen Hosp, Med Educ Ctr, Kaohsiung, Taiwan

[11] Kaohsiung Armed Forced Gen Hosp, Dept Ophthalmol, Kaohsiung, Taiwan

[12] Kaohsiung Armed Forced Gen Hosp, Dept Med, Kaohsiung, Taiwan

[13] Triserv Gen Hosp, Dept Med, Taipei, Taiwan

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2014年 / 22卷 / 02期

关键词：

Rutin; LPS; Acute lung injury; MMP-9; MIP-2; Akt; NF-KAPPA-B; OXIDATIVE STRESS; LIPOPOLYSACCHARIDE; INFLAMMATION; INDUCTION; PATHWAYS; MODEL; MAPK; MICE;

D O I：

10.1016/j.intimp.2014.07.026

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lipopolysaccharide (LPS), also called endotoxin, is the important pathogen of acute lung injury (ALL), which is a clinical syndrome that still lacks effective therapeutic medicine. Rutin belongs to vitamin P and possesses various beneficial effects. In this study, we investigate the potential protective effects and the mechanisms of rutin on LPS-induced ALL. Pre-administration with rutin inhibited LPS-induced arterial blood gas exchange and neutrophils infiltration in the lungs. LPS-induced expression of macrophage inflammatory protein (MIP)-2 and activation of matrix metalloproteinase (MMP)-9 were suppressed by rutin. In addition, the inhibitory concentration of rutin on phosphorylation of Akt was similar as MIP-2 expression and MMP-9 activation. In conclusion, rutin is a potential protective agent for ALL via suppressing the blood gas exchange and neutrophil infiltration. The mechanism of rutin is down-regulation of MIP-2 expression and MMP-9 activation through inhibition of Akt phosphorylation. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：409 / 413

页数：5

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