p53 gene mutation:: software and database

被引：150

作者：

Béroud, C

Soussi, T

机构：

[1] Inst Curie, CNRS, UMR 218, F-75231 Paris 05, France

[2] Hop Necker Enfants Malad, U383 INSERM, Paris, France

来源：

NUCLEIC ACIDS RESEARCH | 1998年 / 26卷 / 01期

关键词：

D O I：

10.1093/nar/26.1.200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A large number of different mutations in the p53 tumor suppressor gene have been identified in all types of cancer. As of October, 1997, this database (http:// perso.curie.fr/tsoussi) contained >7500 mutations. Such a substantial increase since our previous reports should enable epidemiological analyses which were not previously possible. In order to analyse these new data, the UMD software has been improved. A new Web version of the UMD software enables online analysis of the database. The present report describes various improvements since the last release of the database.

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页码：200 / 204

页数：5

相关论文

共 20 条

[1] COMPLETE SEQUENCING OF THE P53 GENE PROVIDES PROGNOSTIC INFORMATION IN BREAST-CANCER PATIENTS, PARTICULARLY IN RELATION TO ADJUVANT SYSTEMIC THERAPY AND RADIOTHERAPY [J].

BERGH, J ;

NORBERG, T ;

SJOGREN, S ;

LINDGREN, A ;

HOLMBERG, L .

NATURE MEDICINE, 1995, 1 (10) :1029-1034

[2] APC gene: Database of germline and somatic mutations in human tumors and cell lines [J].

Beroud, C ;

Soussi, T .

NUCLEIC ACIDS RESEARCH, 1996, 24 (01) :121-124

[3] p53 and APC gene mutations: Software and databases [J].

Beroud, C ;

Soussi, T .

NUCLEIC ACIDS RESEARCH, 1997, 25 (01) :138-138

[4] p53 gene mutation: Software and database [J].

Beroud, C ;

Verdier, F ;

Soussi, T .

NUCLEIC ACIDS RESEARCH, 1996, 24 (01) :147-150

[5] TP53 MUTATIONS AND BREAST-CANCER PROGNOSIS - PARTICULARLY POOR SURVIVAL RATES FOR CASES WITH MUTATIONS IN THE ZINC-BINDING DOMAINS [J].

BORRESEN, AL ;

ANDERSEN, TI ;

EYFJORD, JE ;

CORNELIS, RS ;

THORLACIUS, S ;

BORG, A ;

JOHANSSON, U ;

THEILLET, C ;

SCHERNECK, S ;

HARTMAN, S ;

CORNELISSE, CJ ;

HOVIG, E ;

DEVILEE, P .

GENES CHROMOSOMES & CANCER, 1995, 14 (01) :71-75

[6] A ROLE FOR SUNLIGHT IN SKIN-CANCER - UV-INDUCED P53 MUTATIONS IN SQUAMOUS-CELL CARCINOMA [J].

BRASH, DE ;

RUDOLPH, JA ;

SIMON, JA ;

LIN, A ;

MCKENNA, GJ ;

BADEN, HP ;

HALPERIN, AJ ;

PONTEN, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (22) :10124-10128

[7]

CARIELLO NF, 1994, CANCER RES, V54, P4454

[8] CRYSTAL-STRUCTURE OF A P53 TUMOR-SUPPRESSOR DNA COMPLEX - UNDERSTANDING TUMORIGENIC MUTATIONS [J].

CHO, YJ ;

GORINA, S ;

JEFFREY, PD ;

PAVLETICH, NP .

SCIENCE, 1994, 265 (5170) :346-355

[9] Software and database for the analysis of mutations in the human FBN1 gene [J].

Collod, G ;

Beroud, C ;

Soussi, T ;

Junien, C ;

Boileau, C .

NUCLEIC ACIDS RESEARCH, 1996, 24 (01) :137-140

[10]

DEFROMENTEL CC, 1992, GENE CHROMOSOME CANC, V4, P1