New developments in isotope labeling strategies for protein solution NMR spectroscopy

被引：154

作者：

Goto, NK ^{[1
]}

Kay, LE

机构：

[1] Univ Toronto, Dept Biochem, Toronto, ON M5S 1A8, Canada

[2] Hosp Sick Children, Toronto, ON M5G 1X8, Canada

[3] Univ Toronto, Prot Engn Network Ctr Excellence, Toronto, ON M5S 1A8, Canada

[4] Univ Toronto, Dept Med Genet, Toronto, ON M5S 1A8, Canada

[5] Univ Toronto, Dept Chem, Toronto, ON M5S 1A8, Canada

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2000年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0959-440X(00)00135-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The development of novel isotope labeling strategies for proteins has facilitated the study of the structure and dynamics of these molecules. In addition, the recent emergence of alternative methods of bacterial expression for obtaining isotopically labeled proteins permits the study of new classes of important proteins by solution NMR methods.

引用

页码：585 / 592

页数：8

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