Surgery without radiotherapy for primary treatment of endometrial cancer

被引:99
作者
Larson, DM
Broste, SK
Krawisz, BR
机构
[1] Marshfield Clin Fdn Med Res & Educ, Dept Obstet & Gynecol, Marshfield, WI 54449 USA
[2] Marshfield Clin Fdn Med Res & Educ, Dept Epidemiol & Biostat, Marshfield, WI 54449 USA
[3] Marshfield Clin Fdn Med Res & Educ, Dept Pathol, Marshfield, WI 54449 USA
关键词
D O I
10.1016/S0029-7844(97)00698-4
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To analyze the role of surgery alone, including pelvic and para-aortic lymphadenectomy, in patients with endometrial cancer who did not receive radiotherapy. Methods: Between August 1987 and January 1997, 225 women with disease clinically confined to the uterus were staged surgically by a standard protocol that included pelvic and para-aortic lymphadenectomy in women with high risk factors. No radiation was administered before or after surgery. Results: The combination of preoperative endometrial biopsy grade and gross depth of myometrial invasion identified 123 (55%) high-risk patients who had lymphadenectomy and 102 (45%) low-risk patients who did not. Eighteen (15%) high-risk patients had lymph node metastases and received postoperative systemic therapy. Three low-risk, eight high-risk-node-negative, and no high-risk-node-positive patients were diagnosed with recurrent cancer, corresponding to 5-year recurrence-free proportions of 0.95, 0.89, and 1.00, respectively. Although sample sizes and limited follow-up limit conclusions, the experience to date suggests a high rate of survival in all three groups. Conclusion: Our preliminary experience indicates that even high-risk patients have an excellent prognosis when treated with surgery, including pelvic and para-aortic lymphadenectomy, without radiotherapy. (C) 1998 by The American College of Obstetricians and Gynecologists.
引用
收藏
页码:355 / 359
页数:5
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