Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion

被引：123

作者：

Schweighoffer, E

Vanes, L

Mathiot, A

Nakamura, T

Tybulewicz, VLJ

机构：

[1] Natl Inst Med Res, London NW7 1AA, England

[2] Univ Tokyo, Inst Med Sci, Dept Infect Dis & Appl Immunol, Tokyo 108, Japan

来源：

IMMUNITY | 2003年 / 18卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S1074-7613(03)00082-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

ZAP-70, a member of the Syk family of tyrosine kinases, has been reported to be expressed exclusively in T and NK cells. We show here that it is expressed throughout B cell development and that it plays a role in the transition of pro-B to pre-B cells in the bone marrow, a checkpoint controlled by signals from the pre-B cell receptor (pre-BCR), which monitors for successful rearrangement of immunoglobulin heavy chain genes. Whereas mice deficient in Syk show a partial block at this step, mice mutant in both Syk and ZAP-70 show a complete block at the pro-B cell stage and a failure of heavy chain allelic exclusion, hallmarks of defective pre-BCR signaling.

引用

收藏

页码：523 / 533

页数：11

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