Manganese: Recent advances in understanding its transport and neurotoxicity

被引：471

作者：

Aschner, Michael

Guilarte, Tomas R.

Schneider, Jay S.

Zheng, Wei

机构：

[1] Vanderbilt Univ, Med Ctr N, Dept Pediat, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Med Ctr N, Dept Pharmacol, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Med Ctr N, Kennedy Ctr Res Human Dev, Nashville, TN 37232 USA

[4] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, Neurotoxicol & Mol Imaging Lab, Baltimore, MD USA

[5] Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA USA

[6] Purdue Univ, Sch Hlth Sci, W Lafayette, IN USA

来源：

TOXICOLOGY AND APPLIED PHARMACOLOGY | 2007年 / 221卷 / 02期

关键词：

manganese; Parkinson's disease; transport; neurotoxicity;

D O I：

10.1016/j.taap.2007.03.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present review is based on presentations from the meeting of the Society of Toxicology in San Diego, CA (March 2006). It addresses recent developments in the understanding of the transport of manganese (Mn) into the central nervous system (CNS), as well as brain imaging and neurocognitive studies in non-human primates aimed at improving our understanding of the mechanisms of Mn neurotoxicity. Finally, we discuss potential therapeutic modalities for treating Mn intoxication in humans. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：131 / 147

页数：17

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