A competence regulon in Streptococcus pneumoniae revealed by genomic analysis

被引：119

作者：

Campbell, EA

Choi, SY

Masure, HR

机构：

[1] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA

[2] Rockefeller Univ, Lab Mol Infect Dis, New York, NY 10021 USA

来源：

MOLECULAR MICROBIOLOGY | 1998年 / 27卷 / 05期

关键词：

D O I：

10.1046/j.1365-2958.1998.00737.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transformation in bacteria is the uptake and incorporation of exogenous DNA into a cell's genome. Several species transform naturally during a regulated state defined as competence. Genetic elements in Streptococcus pneumoniae induced during transformation were identified by combining a genetic screen with genomic analysis. Six loci were discovered that composed a competence-induced regulon. These loci shared a consensus promoter sequence and encoded proteins, some of which were similar to proteins involved in DNA processing during transformation in other bacteria. Each locus was induced during competence and essential for genetic transformation.

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收藏

页码：929 / 939

页数：11

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