Heart transplantation in baboons using 1,3-galactosyl transferase gene-knockout pigs as donors: initial experience

被引：557

作者：

Kuwaki, K

Tseng, YL

Dor, FJMF

Shimizu, A

Houser, SL

Sanderson, TM

Lancos, CJ

Prabharasuth, DD

Cheng, J

Moran, K

Hisashi, Y

Mueller, N

Yamada, K

Greenstein, JL

Hawley, RJ

Patience, C

Awwad, M

Fishman, JA

Robson, SC

Schuurman, HJ

Sachs, DH

Cooper, DKC

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Transplantat Biol Res Ctr, Boston, MA 02129 USA

[2] Immerge BioTherapeut Inc, Cambridge, MA 02139 USA

[3] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Pathol, Boston, MA 02114 USA

[4] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Infect Dis, Boston, MA 02114 USA

[5] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Ctr Immunobiol, Boston, MA 02215 USA

来源：

NATURE MEDICINE | 2005年 / 11卷 / 01期

关键词：

D O I：

10.1038/nm1171

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hearts from alpha1,3-galactosyltransferase knockout pigs (GalT-KO, n = 8) were transplanted heterotopically into baboons using an anti-CD154 monoclonal antibody-based regimen. The elimination of the galactose-alpha1,3-galactose epitope prevented hyperacute rejection and extended survival of pig hearts in baboons for 2-6 months (median, 78 d); the predominant lesion associated with graft failure was a thrombotic microangiopathy, with resulting ischemic injury. There were no infectious complications directly related to the immunosuppressive regimen. The transplantation of hearts from GalT-KO pigs increased graft survival over previous studies.

引用

页码：29 / 31

页数：3

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