Mechanisms of cancer cell invasion

被引：420

作者：

Sahai, E ^{[1
]}

机构：

[1] Canc Res UK London Res Inst, Tumor Cell Biol Lab, London WC2A 3PX, England

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2005年 / 15卷 / 01期

关键词：

D O I：

10.1016/j.gde.2004.12.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The movement of cancer cells into tissue surrounding the tumour and the vasculature is the first step in the spread of metastatic cancers. Recent advances in imaging, the use of 3D model systems and the application of microarray technologies have yielded new insights into these processes. This work has challenged our views about what causes cancer cells to become motile in the first place, and has demonstrated that cancer cells can move in many different ways.

引用

页码：87 / 96

页数：10

共 67 条

[1]

Ahmed F, 2002, CANCER RES, V62, P7166

[2]

Aizawa H, 1997, J CELL SCI, V110, P2333

[3]

Andreasen PA, 1997, INT J CANCER, V72, P1, DOI 10.1002/(SICI)1097-0215(19970703)72:1<1::AID-IJC1>3.0.CO

[4]

2-Z

[5] Chemokine biology in cancer [J].

Balkwill, F .

SEMINARS IN IMMUNOLOGY, 2003, 15 (01) :49-55

[6] Integrins in invasive growth [J].

Brakebusch, C ;

Bouvard, D ;

Stanchi, F ;

Saki, T ;

Fässler, R .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (08) :999-1006

[7] FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak [J].

Ciruna, B ;

Rossant, J .

DEVELOPMENTAL CELL, 2001, 1 (01) :37-49

[8] Intravital imaging of cell movement in tumours [J].

Condeelis, J ;

Segall, JE .

NATURE REVIEWS CANCER, 2003, 3 (12) :921-930

[9] Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent proinvasive signals to human colon cancer cells through RhoA and Rac [J].

De Wever, O ;

Nguyen, QD ;

Van Hoorde, L ;

Bracke, M ;

Bruyneel, E ;

Gespach, C ;

Mareel, M .

FASEB JOURNAL, 2004, 18 (06) :1016-+

[10] Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCζ [J].

Etienne-Manneville, S ;

Hall, A .

CELL, 2001, 106 (04) :489-498

← 1 2 3 4 5 6 7 →