Improved synthesis of 5-benzyl-2-thiouracils

被引：5

作者：

Orr, GF ^{[1
]}

Musso, DL ^{[1
]}

机构：

[1] BURROUGHS WELLCOME CO,DIV ORGAN CHEM,RES TRIANGLE PK,NC 27709

来源：

SYNTHETIC COMMUNICATIONS | 1996年 / 26卷 / 01期

关键词：

D O I：

10.1080/00397919608003878

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Improved methodology for the synthesis of 5-benzyl-2-thiouracils from ethyl phenylpropanoates is reported.

引用

页码：179 / 189

页数：11

共 7 条

[1] IRREVERSIBLE ENZYME INHIBITORS .169. INHIBITION OF FUDR PHOSPHORYLASE FROM WALKER-256 RAT TUMOR BY 6-SUBSTITUTED URACILS [J].

BAKER, BR ;

KELLEY, JL .

JOURNAL OF MEDICINAL CHEMISTRY, 1970, 13 (03) :456-&

[2]

BRUCE JM, 1971, J CHEM SOC C, P3749

[3] Researches on pyrimidines CLIX Synthesis of 6-benzyl- and 5-benzyluracils [J].

Johnson, TB ;

Ambelang, JC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1938, 60 :2941-2944

[4] 5-BENZYLACYCLOURIDINE AND 5-BENZYLOXYBENZYLACYCLOURIDINE, POTENT INHIBITORS OF URIDINE PHOSPHORYLASE [J].

NIEDZWICKI, JG ;

CHU, SH ;

ELKOUNI, MH ;

ROWE, EC ;

CHA, S .

BIOCHEMICAL PHARMACOLOGY, 1982, 31 (10) :1857-1861

[5] STRUCTURE ACTIVITY RELATIONSHIP OF LIGANDS OF THE PYRIMIDINE NUCLEOSIDE PHOSPHORYLASES [J].

NIEDZWICKI, JG ;

ELKOUNI, MH ;

CHU, SH ;

CHA, S .

BIOCHEMICAL PHARMACOLOGY, 1983, 32 (03) :399-415

[6] RAPID CHROMATOGRAPHIC TECHNIQUE FOR PREPARATIVE SEPARATIONS WITH MODERATE RESOLUTION [J].

STILL, WC ;

KAHN, M ;

MITRA, A .

JOURNAL OF ORGANIC CHEMISTRY, 1978, 43 (14) :2923-2925

[7] BASE-CATALYZED PREPARATION OF METHYL + ETHYL ESTERS OF CARBOXYLIC ACIDS [J].

STODOLA, FH .

JOURNAL OF ORGANIC CHEMISTRY, 1964, 29 (08) :2490-&

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