Problems with spontaneously hypertensive rats (SHR) as a model of attention-deficit/hyperactivity disorder (AD/HD)

被引：46

作者：

Alsop, Brent ^{[1
]}

机构：

[1] Univ Otago, Dept Psychol, Dunedin, New Zealand

来源：

JOURNAL OF NEUROSCIENCE METHODS | 2007年 / 162卷 / 1-2期

关键词：

spontaneously hypertensive rats; animal models; free-operant procedures; attention-deficit hyperactivity disorder;

D O I：

10.1016/j.jneumeth.2006.12.002

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Spontaneously hypertensive rats (SHR) have been promoted as animal models of attention-deficit hyperactivity disorder (AD/HD). Free-operant experiments have compared the effects of simple schedules, extinction, delayed reinforcers, and non-contingent reinforcement on the behaviour of SHR and Wistar Kyoto (WKY) controls. Differences between SHR and WKY performance have been paralleled with the overactivity, impulsiveness, and inattention that characterize AD/HD. Re-examination of selected studies suggests that differences in these strains' overall response rates can exaggerate other differences between SHR and WKY performance. Removing this confounding factor can reduce differences between these two strains' behaviours. (C) 2006 Elsevier B.V. All rights reserved.

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收藏

页码：42 / 48

页数：7

相关论文

共 13 条

[1] Sex differences in operant discrimination behaviour in an animal model of attention-deficit hyperactivity disorder [J].

Berger, DF ;

Sagvolden, T .

BEHAVIOURAL BRAIN RESEARCH, 1998, 94 (01) :73-82

[2] Chronic L-deprenyl treatment alters brain monoamine levels and reduces impulsiveness in an animal model of Attention-Deficit/Hyperactivity Disorder [J].

Boix, F ;

Qiao, SW ;

Kolpus, T ;

Sagvolden, T .

BEHAVIOURAL BRAIN RESEARCH, 1998, 94 (01) :153-162

[3] Comparisons of behavioral and neurochemical characteristics between WKY, WKHA, and Wistar rat strains [J].

Drolet, G ;

Proulx, K ;

Pearson, D ;

Rochford, J ;

Deschepper, CF .

NEUROPSYCHOPHARMACOLOGY, 2002, 27 (03) :400-409

[4] Behavioral effects of intra-cranial self-stimulation in an animal model of attention-deficit/hyperactivity disorder (ADHD) [J].

Johansen, EB ;

Sagvolden, T .

BEHAVIOURAL BRAIN RESEARCH, 2005, 162 (01) :32-46

[5] Slower extinction of responses maintained by intra-cranial self-stimulation (ICSS) in an animal model of attention-deficit/hyperactivity disorder (ADHD) [J].

Johansen, EB ;

Sagvolden, T .

BEHAVIOURAL BRAIN RESEARCH, 2005, 162 (01) :22-31

[6] Effects of delayed reinforcers on the behavior of an animal model of attention-deficit/hyperactivity disorder (ADHD) [J].

Johansen, EB ;

Sagvolden, T ;

Kvande, G .

BEHAVIOURAL BRAIN RESEARCH, 2005, 162 (01) :47-61

[7] Diagnostic and Statistical Manual of Mental Disorders [J].

Mittal, Vijay A. ;

Walker, Elaine F. .

PSYCHIATRY RESEARCH, 2011, 189 (01) :158-159

[8] Behavioral validation of the spontaneously hypertensive rat (SHR) as an animal model of attention-deficit/hyperactivity disorder (AD/HD) [J].

Sagvolden, T .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2000, 24 (01) :31-39

[9] SPONTANEOUSLY HYPERTENSIVE RATS (SHR) AS A PUTATIVE ANIMAL-MODEL OF CHILDHOOD HYPERKINESIA - SHR BEHAVIOR COMPARED TO 4 OTHER RAT STRAINS [J].

SAGVOLDEN, T ;

PETTERSEN, MB ;

LARSEN, MC .

PHYSIOLOGY & BEHAVIOR, 1993, 54 (06) :1047-1055

[10] Rodent models of attention-deficit/hyperactivity disorder [J].

Sagvolden, T ;

Russell, VA ;

Aase, H ;

Johansen, EB ;

Farshbaf, M .

BIOLOGICAL PSYCHIATRY, 2005, 57 (11) :1239-1247