Differences in plasma concentrations of the D- and L-threo methylphenidate enantiomers in responding and non-responding children with attention-deficit hyperactivity disorder

被引：12

作者：

Jonkman, LM

Verbaten, MN

de Boer, D

Maes, RAA

Buitelaar, JK

Kemner, C

van Engeland, H

Koelega, HS

机构：

[1] Univ Utrecht, Dept Psychon, Fac Social Sci, Psychol Lab, NL-3508 TC Utrecht, Netherlands

[2] Univ Utrecht, Rudolf Magnus Inst Neurosci, Dept Psychopharmacol, Fac Pharm, Utrecht, Netherlands

[3] Univ Utrecht, Dept Child & Adolescent Psychiat, Utrecht, Netherlands

来源：

PSYCHIATRY RESEARCH | 1998年 / 78卷 / 1-2期

关键词：

evoked potentials; P300; attention;

D O I：

10.1016/S0165-1781(97)00138-8

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Children with attention-deficit hyperactivity disorder who are categorized as responders or non-responders to methylphenidate (MPH) on the basis of their electrophysiological P3 response in a selective attention task differ in metabolic patterns of the D-and L-threo MPH enantiomers. Non-responders showed significantly higher plasma concentrations of both D-and L-threo MPH enantiomers. (C) 1998 Elsevier Science Ireland Ltd.

引用

页码：115 / 118

页数：4

共 6 条

[1]

GUALTIERI CT, 1988, ATTENTION DEFICIT DI, V3, P81

[2] ENANTIOSELECTIVE ASPECTS OF THE DISPOSITION OF DL-THREO-METHYLPHENIDATE AFTER THE ADMINISTRATION OF A SUSTAINED-RELEASE FORMULATION TO CHILDREN WITH ATTENTION DEFICIT-HYPERACTIVITY DISORDER [J].