Clozapine eligibility among state hospital patients

被引:96
作者
Essock, SM
Hargreaves, WA
Dohm, FA
Goethe, J
Carver, L
Hipshman, L
机构
[1] UNIV CONNECTICUT,AJ PAPPANIKOU CTR,STORRS,CT
[2] UNIV CALIF SAN FRANCISCO,SAN FRANCISCO,CA 94143
[3] WESLEYAN UNIV,NEW ENGLAND WOMENS HLTH PROJECT,MIDDLETOWN,CT
[4] INST LIVING,HARTFORD,CT
[5] NORWICH HOSP,NORWICH,CT
[6] UNIV ZIMBABWE,DEPT PSYCHIAT,SCH MED,HARARE,ZIMBABWE
[7] YALE UNIV,SCH MED,NEW HAVEN,CT
[8] CONNECTICUT VALLEY HOSP,PROFESS SERV,MIDDLETOWN,CT
关键词
D O I
10.1093/schbul/22.1.15
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Connecticut State Hospital's entire resident population (n = 1,300) was screened on an arbitrary target day to determine eligibility for clozapine. Sixty percent of 803 patients with schizophrenia or schizoaffective disorder diagnoses met Food and Drug Administration (FDA)approved criteria for clozapine use as judged by review of past medication trial records and by the responsible physician. Eighty-eight percent of these patients were medically cleared, and of those cleared, 63 percent agreed to clozapine treatment. Of the patients who began a clozapine trial, 76 percent were still taking the drug 12 months later. Preliminary findings from a randomized trial of clozapine versus usual care (n = 227) indicate that discharge rates associated with clozapine and usual care do not differ. Once discharged, however, patients assigned to clozapine are less likely to be readmitted. Hence, clozapine may be more cost-effective than usual care. However, before savings can be realized, State governments will have to make up-front investments of approximately $140 million simply to give patients hospitalized on a single day a year's access to clozapine.
引用
收藏
页码:15 / 25
页数:11
相关论文
共 25 条
  • [1] Association A.P., 1987, Diagnostic and Statistical Manual of Mental Disorders-Revision
  • [2] CHILES JA, 1994, HOSP COMMUNITY PSYCH, V45, P269
  • [3] DENNIS JL, 1993, 4 ANN NAT C STAT MEN
  • [4] ESSOCK SM, 1995, AM J PSYCHIAT, V152, P152
  • [5] Fleiss JL., 1981, MEASUREMENT INTERRAT
  • [6] FRANK RG, 1991, HOSP COMMUNITY PSYCH, V42, P92
  • [7] GOLDMAN HH, 1991, HOSP COMMUNITY PSYCH, V42, P92
  • [8] HONIGFELD G, 1990, HOSP COMMUNITY PSYCH, V41, P882
  • [9] JUAREZREYES MG, 1995, PSYCHIAT SERV, V46, P801
  • [10] KANE J, 1988, ARCH GEN PSYCHIAT, V45, P789