Serum lipids and hippocampal volume: The link to Alzheimer's disease?

被引：95

作者：

Wolf, H

Hensel, A

Arendt, T

Kivipelto, M

Winblad, B

Gertz, HJ

机构：

[1] Karolinska Inst, Dept Neurotec, Div Clin Geriatr, Aging Res Ctr, S-11382 Stockholm, Sweden

[2] Univ Leipzig, Dept Psychiat, Leipzig, Germany

[3] Univ Leipzig, Paul Flechsig Inst Brain Res, Leipzig, Germany

来源：

ANNALS OF NEUROLOGY | 2004年 / 56卷 / 05期

关键词：

D O I：

10.1002/ana.20289

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The association between hippocampal volume (as a presumed index of Alzheimer's disease pathology) with serum total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol was studied in 86 elderly subjects with a range of cognitive functions. High-density lipoprotein cholesterol, but not low-density lipoprotein cholesterol or total cholesterol, was associated with hippocampal volume and dementia. This is compatible with protective effects of high-density lipoprotein cholesterol on hippocampal atrophy and Alzheimer's disease.

引用

页码：745 / 748

页数：4

共 16 条

[1] Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: the 'Dr. Jekyll and Mr. Hyde concept' of Alzheimer's disease or the yin and yang of neuroplasticity [J].