Chronic morphine treatment inhibits oxytocin synthesis in rats

被引：42

作者：

You, ZD ^{[1
]}

Li, JH ^{[1
]}

Song, CY ^{[1
]}

Wang, CH ^{[1
]}

Lu, CL ^{[1
]}

机构：

[1] Second Mil Med Univ, Dept Neurobiol, Shanghai 200433, Peoples R China

来源：

NEUROREPORT | 2000年 / 11卷 / 14期

关键词：

in situ hybridization; micropunch; morphine dependence; naloxone; oxytocin; radioimmunoassay; rats; supraoptic nucleus;

D O I：

10.1097/00001756-200009280-00015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The changes of oxytocin content and mRNA expression in some nuclei were investigated in morphine-dependent rats using radioimmunoassay (RIA) and in situ hybridization (ISH). After chronic administration of morphine, the oxytocin content in supraoptic nucleus (SON) and nucleus accumbens (NAc) decreased, and increased in the ventral tegment area (VTA) and locus coeruleus (LC), but did not change in other nuclei including the paraventricular nucleus (PVN), lateral septum (SEPTUM), raphe magnus nucleus (NRM) and periaquaductal gray (PAG). In morphine-L dependent rats, naloxone increased the levels of oxytocin in SON and PVN, but decreased that in LC. ISH first showed that chronic morphine treatment inhibited the oxytocin synthesis in SON but not in PVN. The present study demonstrates that chronic morphine treatment alters the brain oxytocin system, suggesting that oxytocin might contribute to the behavioral and neuroendocrine responses to morphine. NeuroReport 11:3113-3116 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：3113 / 3116

页数：4

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