Age-related susceptibility to oxygen and glucose deprivation damage in rat hippocampal slices

被引：33

作者：

Siqueira, IR

Cimarosti, H

Fochesatto, C

Salbego, C

Netto, CA

机构：

[1] Univ Fed Rio Grande Sul, Dept Bioquim, BR-90830250 Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande Sul, Programa Pos Grad Ciencias Biol Fisiol, Porto Alegre, RS, Brazil

[3] Ctr Univ Univates, Lajeado, RS, Brazil

来源：

BRAIN RESEARCH | 2004年 / 1025卷 / 1-2期

关键词：

aging; susceptibility to ischemia; oxygen and glucose deprivation; hippocampal slice; LDH release; MTT; DCF;

D O I：

10.1016/j.brainres.2004.08.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Aging is an important risk factor for stroke. We evaluated the effects of aging on cell susceptibility to oxygen and glucose deprivation (OGD) in slices of the hippocampus from Wistar rats aged 2, 11 and 24 months. Lactate dehydrogenase (LDH) released to the incubation media and free radical content were markedly increased in the 24-month group submitted to OGD. These results confirm that hippocampal tissue from old animals is more susceptible to ischemia-reoxygenation injury. (C) 2004 Elsevier B.V. All rights reserved.

引用

收藏

页码：226 / 230

页数：5

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