Cell wall active antifungal compounds produced by the marine fungus Hypoxylon oceanicum LL-15G256

被引：30

作者：

Abbanat, D

Leighton, M

Maiese, W

Jones, EBG

Pearce, C

Greestein, M

机构：

[1] Wyeth Ayerst Res, Nat Prod Res, Pearl River, NY 10965 USA

[2] City Univ Hong Kong, Dept Biol & Chem, Kowloon, Peoples R China

来源：

JOURNAL OF ANTIBIOTICS | 1998年 / 51卷 / 03期

关键词：

D O I：

10.7164/antibiotics.51.296

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The cell wall targeted antifungal activity of Hypoxylon oceanicum LL-15G256 extracts resulted from the production of novel lipodepsipeptides and previously reported macrocyclic polylactones. In an optimized medium, titers of the lipodepsipeptide and the polylactones reached approximately 200 similar to 400 mg/liter and 25 similar to 50 mg/liter, respectively. The optimum fermentation temperature for production of 15G256 gamma was 28 degrees C. Seawater appeared to have an inhibitory effect on metabolite accumulation at lower fermentation temperatures.

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页码：296 / 302

页数：7

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