Neural cell adhesion molecules, CaM kinase II and long-term memory in the chick

被引:19
作者
Solomonia, RO
Kiguradze, T
McCabe, BJ [1 ]
Horn, G
机构
[1] Univ Cambridge, Subdept Anim Behav, Dept Zool, Cambridge CB3 8AA, England
[2] Georgian Acad Sci, Inst Physiol, GE-380060 Tbilisi, Georgia
关键词
CaMKII alpha; domestic chick; hyperstriatum accessorium; IMHV; imprinting; intermediate and medial hyperstriatum ventralis; learning; memory; NCAM;
D O I
10.1097/00001756-200009280-00020
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The intermediate and medial hyperstriatum ventrale (IMHV) of the chick brain is a site of recognition memory for filial imprinting. Previous results have demonstrated learning-related changes in the amounts of the three major isoforms of neural cell adhesion molecule (NCAM) in the left IMHV. The increases were present 24 h after training. The present study enquired whether the increases persisted and were present 48 h after training. The brain regions analysed were the left and right IMHV and the left and right hyperstriatum accessorium (HA), a visual projection area. The alpha-subunit of calcium/calmodulin protein kinase II (CaMKII alpha) was also assayed. There were significant correlations between a measure of the strength of learning and the amount of NCAM 180 in the right IMHV (r = +0.65; p = 0.012) but not in the left, and in the left HA (r = -0.61; p = 0.02), but not in the right. There were no learning-related changes for CaMKII alpha. We conclude that in IMHV the effects of imprinting on NCAM 180 are expressed mainly in the left IMHV 24 h after training, but 48 h after training are expressed mainly in the right IMHV. NeuroReport 11:3139-3143 (C) 2000 Lippincott Williams & Wilkins.
引用
收藏
页码:3139 / 3143
页数:5
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