Enhanced epinephrine-induced platelet aggregation in individuals carrying the G protein β3 subunit 825T allele

被引：39

作者：

Naber, C

Hermann, BL

Vietzke, D

Altmann, C

Haude, M

Mann, K

Rosskopf, D

Siffert, W

机构：

[1] Univ Essen Gesamthsch Klinikum, Zentrum Innere Med, Abt Kardiol, D-45147 Essen, Germany

[2] Univ Essen Gesamthsch Klinikum, Abt Endokrinol, D-45147 Essen, Germany

[3] Univ Essen Gesamthsch Klinikum, Inst Pharmakol, D-45147 Essen, Germany

来源：

FEBS LETTERS | 2000年 / 484卷 / 03期

关键词：

calcium; human; gene; platelet; G protein; epinephrine;

D O I：

10.1016/S0014-5793(00)02158-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 825T allele of a common C825T polymorphism in the gene encoding the beta3 subunit of heterotrimeric G proteins is associated with enhanced activation of pertussis toxin (PTX)sensitive G proteins. We investigated responses of human platelets upon stimulation with epinephrine, which activates PTX-sensitive G proteins, and with agonists which activate additionally, or exclusively PTS-insensitive pathways, Slopes and maximum of the secondary aggregation were significantly enhanced in platelets from 825T allele carriers after epinephrine, and after combined epinephrine/ADP. This effect was more pronounced after inhibition of the cyclooxygenase-2 pathway by acetylsalicylic acid. This phenomenon appeared independent of platelet secretion, or inhibition of the adenylyl cyclase, (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B,V, All rights reserved.

引用

页码：199 / 201

页数：3

共 20 条

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