Structure-function relationships of HIV-1 envelope sequence-variable regions refocus vaccine design

被引：129

作者：

Zolla-Pazner, Susan ^{[1
,2
]}

Cardozo, Timothy ^{[3
]}

机构：

[1] Harbor Healthcare Syst, Vet Affairs New York, New York, NY 10010 USA

[2] New York Univ, Dept Pathol, Sch Med, New York, NY 10016 USA

[3] New York Univ, Dept Pharmacol, Sch Med, New York, NY 10016 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2010年 / 10卷 / 07期

基金：

美国国家卫生研究院;

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; HUMAN MONOCLONAL-ANTIBODIES; EPITOPE FINE SPECIFICITY; N-LINKED GLYCOSYLATION; AMINO-ACID CHANGES; MEMORY B-CELL; NEUTRALIZING ANTIBODIES; BINDING-SITE; V3; LOOP; HIV-1-INFECTED INDIVIDUALS;

D O I：

10.1038/nri2801

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

One of the main challenges of developing an HIV-1 vaccine lies in eliciting immune responses that can overcome the antigenic variability exhibited by HIV. Most HIV-1 vaccine development has focused on inducing immunity to conserved regions of the HIV-1 envelope. However, new studies of the sequence-variable regions of the HIV-1 gp120 envelope glycoprotein have shown that there are conserved immunological and structural features in these regions. Recombinant immunogens that include these features may provide the means to address the antigenic diversity of HIV-1 and induce protective antibodies that can prevent infection with HIV-1.

引用

页码：527 / 535

页数：9

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