1,1,3,3-Tetraisopropyl-3-(2-(triphenylmethoxy)ethoxy)disiloxane-1-yl group, a potential 5′-O-protecting group for solid-phase RNA synthesis

被引：4

作者：

Hirao, I

Koizumi, M

Ishido, Y

Andrus, A

机构：

[1] RIKEN, Inst Phys & Chem Res, Yokoyama CytoLog Project, ERATO,JST, Wako, Saitama 35101, Japan

[2] Tokyo Coll Pharm, Lab Pharmaceut Chem, Hachioji, Tokyo 19203, Japan

[3] Appl Biosyst Inc, Foster City, CA 94404 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 19期

关键词：

D O I：

10.1016/S0040-4039(98)00440-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1, 1, 3, 3-Tetraisopropyl-3-(2-(triphenylmethoxy)ethoxy)disiloxane-1-yl (TES) group was designed for solid-phase RNA synthesis as a 5'-O-protecting group, which can be combined with the tetrahydropyranyl group, a 2'-hydroxyl protecting group. The TES group can be selectively introduced to the 5'-hydroxy group of nucleosides and can be easily removed by 0.1M tetrabutylammonium fluoride or 0.01M hydrochloric acid. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：2989 / 2992

页数：4

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