Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey

被引：152

作者：

Boraud, T ^{[1
]}

Bezard, E ^{[1
]}

Guehl, D ^{[1
]}

Bioulac, B ^{[1
]}

Gross, C ^{[1
]}

机构：

[1] Univ Bordeaux 2, Neurophysiol Lab, CNRS UMR 5543, Basal Gang Lab, F-33076 Bordeaux, France

来源：

BRAIN RESEARCH | 1998年 / 787卷 / 01期

关键词：

Parkinson's disease; MPTP-treated monkey; L-DOPA; unit recordings of the globus pallidus (GPe; GPi);

D O I：

10.1016/S0006-8993(97)01563-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied the effects of L-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPI, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During L-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of L-DOPA on GPi output is limited. (C) 1998 Elsevier Science B.V.

引用

页码：157 / 160

页数：4

共 20 条

[1] THE FUNCTIONAL-ANATOMY OF BASAL GANGLIA DISORDERS [J].