Michael addition of ethyl acetoacetate to α,β-unsaturated oximes in the presence of FeCl3:: a novel synthetic route to substituted nicotinic acid derivatives

被引：33

作者：

Chibiryaev, AM

De Kimpe, N

Tkachev, AV

机构：

[1] Novosibirsk Organ Chem Inst, Novosibirsk 630090, Russia

[2] Novosibirsk State Univ, Dept Nat Sci, Novosibirsk 630090, Russia

[3] State Univ Ghent, Fac Agr & Appl Biol Sci, Dept Organ Chem, B-9000 Ghent, Belgium

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 41期

基金：

俄罗斯基础研究基金会;

关键词：

Michael addition; iron(III) chloride hexahydrate; unsaturated oxime; nicotinic acid;

D O I：

10.1016/S0040-4039(00)01391-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The FeCl3-catalyzed reaction of alpha,beta-unsaturated oximes with ethyl acetoacetate resulted in Michael addition followed by ring closure to produce substituted nicotinic acid derivatives in a very efficient way. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：8011 / 8013

页数：3

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