Michael addition of ethyl acetoacetate to α,β-unsaturated oximes in the presence of FeCl3:: a novel synthetic route to substituted nicotinic acid derivatives

被引:33
作者
Chibiryaev, AM
De Kimpe, N
Tkachev, AV
机构
[1] Novosibirsk Organ Chem Inst, Novosibirsk 630090, Russia
[2] Novosibirsk State Univ, Dept Nat Sci, Novosibirsk 630090, Russia
[3] State Univ Ghent, Fac Agr & Appl Biol Sci, Dept Organ Chem, B-9000 Ghent, Belgium
基金
俄罗斯基础研究基金会;
关键词
Michael addition; iron(III) chloride hexahydrate; unsaturated oxime; nicotinic acid;
D O I
10.1016/S0040-4039(00)01391-5
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The FeCl3-catalyzed reaction of alpha,beta-unsaturated oximes with ethyl acetoacetate resulted in Michael addition followed by ring closure to produce substituted nicotinic acid derivatives in a very efficient way. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:8011 / 8013
页数:3
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