Mechanism of inactivation of murine norovirus-1 by high pressure processing

被引:54
作者
Tang, Qingjuan [1 ]
Li, Dan [1 ]
Xu, Jie [1 ]
Wang, Jingfeng [1 ]
Zhao, Yuran [2 ]
Li, Zhaojie [1 ]
Xue, Changhu [1 ]
机构
[1] Ocean Univ China, Coll Food Sci & Engn, Qingdao 266003, Shandong, Peoples R China
[2] Shandong Entry Exit Inspect & Quarantine Bur, Ctr Tech, Qingdao 266003, Shandong, Peoples R China
关键词
High-pressure processing; Murine norovirus-1; Mechanism; Capsid protein; FELINE CALICIVIRUS; VIRUSES; MACROPHAGES; RECEPTORS; CELLS;
D O I
10.1016/j.ijfoodmicro.2009.10.033
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Murine norovirus-1 (MNV) is currently the most suitable surrogate for human norovirus. The mechanism of MNV-1 inactivation by high pressure processing (HPP) was investigated. HPP-treated MNV could not bind to its target receptor and therefore could not initiate infection of mouse RAW cells. The integrity of the capsid was not affect by HPP. Partial motif changes of the viral capsid caused by HPP were accessed by induced sensitivity to proteinase K. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:186 / 189
页数:4
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