α-pompilidotoxin (α-PMTX), a novel neurotoxin from the venom of a solitary wasp, facilitates transmission in the crustacean neuromuscular synapse

被引：38

作者：

Konno, K

Miwa, A

Takayama, H

Hisada, M

Itagaki, Y

Naoki, H

Yasuhara, T

Kawai, N ^{[1
]}

机构：

[1] Jichi Med Sch, Dept Physiol, Minami Kawachi, Tochigi 32904, Japan

[2] Teikyo Univ, Fac Pharmaceut Sci, Kanagawa 19901, Japan

[3] Tokyo Metropolitan Inst Neurosci, Dept Neurobiol, Tokyo 183, Japan

[4] Suntory Inst Bioorgan Res, Osaka 618, Japan

[5] Tokyo Univ Agr, Jr Coll Agr, Dept Nutr, Setagaya Ku, Tokyo 156, Japan

来源：

NEUROSCIENCE LETTERS | 1997年 / 238卷 / 03期

关键词：

neurotoxin; wasp venom; neuromuscular transmission; alpha-pompilidotoxin; lobster neuromuscular synapse; facilitatory toxin;

D O I：

10.1016/S0304-3940(97)00849-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A new neurotoxin, named alpha-pompilidotoxin (alpha-PMTX) has been found in the venom of the solitary wasp Anoplius safnariensis. In the neuromuscular synapse of the lobster walking leg preparation, alpha-PMTX (10-100 mu M) caused great enhancement of both the excitatory and inhibitory postsynaptic potentials. Recordings of the excitatory post synaptic currents (EPSCs) at the synaptic sites showed that alpha-PMTX reversibly and dose-dependently potentiates EPSCs. alpha-PMTX may act primarily on the presynaptic membrane but the mode of action of the toxin is clearly different from other known facilitatory neurotoxins, such as alpha-latrotoxin, apamin or charybdotoxin. This novel toxin will serve as a useful tool in the research field of neuroscience. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：99 / 102

页数：4

共 20 条

[1] EFFECTS OF A SPIDER TOXIN ON THE GLUTAMINERGIC SYNAPSE OF LOBSTER MUSCLE [J].