IL-25 in allergic inflammation

被引：149

作者：

Xu, Miao

Dong, Chen ^{[1
,2
]}

机构：

[1] Tsinghua Univ, Inst Immunol, Beijing, Peoples R China

[2] Tsinghua Univ, Sch Med, Beijing, Peoples R China

来源：

IMMUNOLOGICAL REVIEWS | 2017年 / 278卷 / 01期

关键词：

allergic diseases; cell source; cell target; cytokines; IL-25; IL-25-mediated diseases; INNATE LYMPHOID-CELLS; AIRWAY INFLAMMATION; IN-VIVO; INTERLEUKIN-17; RECEPTOR; PULMONARY INFLAMMATION; IMMUNE-RESPONSES; ADAPTER PROTEIN; TYPE-2; IMMUNITY; CYTOKINE IL-25; FAMILY-MEMBERS;

D O I：

10.1111/imr.12558

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

IL-25, also known as IL-17E, is a member of the IL-17 cytokine family mostly produced by epithelial cells and innate immune cells. After binding to the IL-17RB/IL-17RA complex, IL-25 induces downstream signaling responses in epithelial cells and type 2 lymphocytes, which initiates, propagates, and sustains type 2 immunity. The function of IL-25 in allergic diseases such as asthma has been well established, and now also is extended to diseases such as inflammatory bowel disease and cancer. This review summarizes the literature on IL-25 and discusses the unsolved questions. Our knowledge on IL-25 will pave the pathway for targeting this cytokine in inflammatory diseases.

引用

页码：185 / 191

页数：7

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