A BAF-centred view of the immune system

被引：72

作者：

Chi, T ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2004年 / 4卷 / 12期

关键词：

D O I：

10.1038/nri1501

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chromatin structure dictates whether DNA templates are accessible to nuclear proteins; therefore, it is tightly regulated. To reconfigure chromatin, cells often mobilize 'chromatin-remodelling complexes' that use energy to disrupt histone-DNA contacts. BAF complexes, which are related to the yeast SWI-SNF complex, are the prototypical mammalian chromatin-remodelling complexes. In the past few years, studies have revealed the crucial and diverse roles of BAF complexes in the regulation of the immune system - from lymphocyte development to immune responses. This review surveys these advances, highlighting the general insights these studies provide into the modes of action of BAF complexes, and it concludes with a discussion of some of the key opportunities and challenges in this field.

引用

页码：965 / 977

页数：13

共 93 条

[1] Deciphering the transcriptional histone acetylation code for a human gene [J].

Agalioti, T ;

Chen, GY ;

Thanos, D .

CELL, 2002, 111 (03) :381-392

[2] Ordered recruitment of chromatin modifying and general transcription factors to the IFN-β promoter [J].

Agalioti, T ;

Lomvardas, S ;

Parekh, B ;

Yie, JM ;

Maniatis, T ;

Thanos, D .

CELL, 2000, 103 (04) :667-678

[3] Chromatin-based regulatory mechanisms governing cytokine gene transcription [J].

Agarwal, S ;

Viola, JPB ;

Rao, A .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1999, 103 (06) :990-999

[4] Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes [J].

Belandia, B ;

Orford, RL ;

Hurst, HC ;

Parker, MG .

EMBO JOURNAL, 2002, 21 (15) :4094-4103

[5] CIITA coordinates multiple histone acetylation modifications at the HLA-DRA promoter [J].

Beresford, GW ;

Boss, JM .

NATURE IMMUNOLOGY, 2001, 2 (07) :652-657

[6] Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha [J].

Bhattacharya, S ;

Eckner, R ;

Grossman, S ;

Oldread, E ;

Arany, Z ;

DAndrea, A ;

Livingston, DM .

NATURE, 1996, 383 (6598) :344-347

[7] Growth inhibition by the mammalian SWI-SNF subunit Brm is regulated by acetylation [J].

Bourachot, B ;

Yaniv, M ;

Muchardt, C .

EMBO JOURNAL, 2003, 22 (24) :6505-6515

[8] A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes [J].

Bultman, S ;

Gebuhr, T ;

Yee, D ;

La Mantia, C ;

Nicholson, J ;

Gilliam, A ;

Randazzo, F ;

Metzger, D ;

Chambon, P ;

Crabtree, G ;

Magnuson, T .

MOLECULAR CELL, 2000, 6 (06) :1287-1295

[9] Signaling to chromatin through histone modifications [J].

Cheung, P ;

Allis, CD ;

Sassone-Corsi, P .

CELL, 2000, 103 (02) :263-271

[10] Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development [J].

Chi, TH ;

Wan, MM ;

Lee, PP ;

Akashi, K ;

Metzger, D ;

Chambon, P ;

Wilson, CB ;

Crabtree, GR .

IMMUNITY, 2003, 19 (02) :169-182

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