Large clinical trials in musculoskeletal trauma: Are they possible? Lessons learned from the international study of the use of rhBMP-2 in open tibial fractures

被引：20

作者：

Csimma, C

Swiontkowski, MF

机构：

[1] Wyeth Res, Cambridge, MA 02140 USA

[2] Univ Minnesota, Dept Orthopaed Surg, Minneapolis, MN 55454 USA

来源：

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME | 2005年 / 87A卷 / 01期

关键词：

D O I：

10.2106/JBJS.D.01938

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

[No abstract available]

引用

页码：218 / 222

页数：5

共 4 条

[1]

*COMM PROPR MED PR, 2001, POINTS CONS APPL MET, P99

[2]

CSIMMA C, 2000, BRIT ORTH ASS JAP OR

[3] Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures -: A prospective, controlled, randomized study of four hundred and fifty patients [J].

Govender, S ;

Csimma, C ;

Genant, HK ;

Valentin-Opran, A ;

Amit, Y ;

Arbel, R ;

Aro, H ;

Atar, D ;

Bishay, M ;

Börner, MG ;

Chiron, P ;

Choong, P ;

Cinats, J ;

Courtenay, B ;

Feibel, R ;

Geulette, B ;

Gravel, C ;

Haas, N ;

Raschke, M ;

Hammacher, E ;

van der Velde, D ;

Hardy, P ;

Holt, M ;

Josten, C ;

Ketterl, RL ;

Lindeque, B ;

Lob, G ;

Mathevon, H ;

Mccoy, G ;

Marsh, D ;

Miller, R ;

Munting, E ;

Oevre, S ;

Nordsletten, L ;

Patel, A ;

Pohl, A ;

Rennie, W ;

Reynders, P ;

Rommens, PM ;

Rondia, J ;

Rossouw, WC ;

Daneel, PJ ;

Ruff, S ;

Rüter, A ;

Santavirta, S ;

Schildhauer, TA ;

Gekle, C ;

Schnettler, R ;

Segal, D ;

Seiler, H .

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2002, 84A (12) :2123-2134

[4] Type-II error rates (beta errors) of randomized trials in orthopaedic trauma [J].

Lochner, HV ;

Bhandari, M ;

Tornetta, P .

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2001, 83A (11) :1650-1655

← 1 →