Practical synthesis of (S)-7-(2-isopropylamino)ethylcamptothecin hydrochloride, potent topoisomerase I inhibitor

被引：36

作者：

Ahn, SK

Choi, NS

Jeong, BS

Kim, KK

Journ, DJ

Kim, JK

Lee, SJ

Kim, JW

Hong, CI

Jew, SS

机构：

[1] Chong Kun Dang Res Inst, Cheonan 330830, Chungcheongnamd, South Korea

[2] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2000年 / 37卷 / 05期

关键词：

D O I：

10.1002/jhet.5570370519

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical semi-synthetic method of (S)-7-(2-isopropylamino)ethylcamptothecin hydrochloride has been developed. The Mannich reaction of (S)-7-methylcamptothecin with isopropylamine hydrochloride in dimethyl sulfoxide as a formaldehyde source gave the desired product in moderate yield.

引用

页码：1141 / 1144

页数：4

共 16 条

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