Lithium lengthens the circadian period of individual suprachiasmatic nucleus neurons

被引：127

作者：

Abe, M ^{[1
]}

Herzog, ED ^{[1
]}

Block, GD ^{[1
]}

机构：

[1] Univ Virginia, Dept Biol, NSF Sci Biol Timing, Charlottesville, VA 22903 USA

来源：

NEUROREPORT | 2000年 / 11卷 / 14期

关键词：

depression; diurnal; hypothalamus; multi-electrode; pacemaker; rhythm; SCN;

D O I：

10.1097/00001756-200009280-00042

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Lithium treatment lengthens the period of circadian rhythms in most organisms. In the present study, we tested whether lithium acts directly on the mammalian suprachiasmatic nucleus (SCN) to lengthen rhythms of individual neurons. Lithium increased the circadian period of firing rate rhythms of cultured SCN neurons in a concentration-dependent manner. Lithium had no effect on the amplitude of these rhythms, but did affect the period of some cells more than others. The results indicate that lithium acts directly on the SCN to lengthen the free-running period of individual neurons. NeuroReport 11:3261-3264 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：3261 / 3264

页数：4

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