Histone deacetylases and cancer: Causes and therapies

被引：1611

作者：

Marks, PA

Rifkind, RA

Richon, VM

Breslow, R

Miller, T

Kelly, WK

机构：

[1] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

[2] Columbia Univ, New York, NY 10027 USA

来源：

NATURE REVIEWS CANCER | 2001年 / 1卷 / 03期

关键词：

D O I：

10.1038/35106079

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Together, histone acetyltransferases and histone deacetylases (HDACs) determine the acetylation status of histones. This acetylation affects the regulation of gene expression, and inhibitors of HDACs have been found to cause growth arrest, differentiation and/or apoptosis of many tumours cells by altering the transcription of a small number of genes. HDAC inhibitors are proving to be an exciting therapeutic approach to cancer, but how do they exert this effect?.

引用

页码：194 / 202

页数：9

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